In Episode 2 of Med School Question of the Week for USMLE, Sam Taylor, MedSchoolCoach expert tutor, answers this medical school question: A 52 year-old woman comes to clinic for evaluation of hot flashes. The hot flashes often kept her up at night and distract her while she is at work. She also has been having increasingly irregular periods for the past several years and her last period was 4 months ago. She has a history of hypertriglyceridemia and takes no medications. She is prescribed a transdermal path containing estrogen. Compared to oral, transdermal hormone administration will best mitigate which risks?