In Episode 31 of Med School Question of the Week for USMLE, Alisa Khomutova, MedSchoolCoach expert tutor, answers this medical school question: A 28-year-old man presents to the Ed with complaints of shortness of breath and hemoptysis over the past week. He has no known sick contacts. He has no PMH and drinks a few bottles of beer on the weekend. He takes no medications. His temperature is 37°C(98.6°F), pulse is 91/min, respirations are 21/min, and blood pressure is 148/89 mm Hg. Physical exam shows inspiratory crackles at both lung bases. The remainder of the exam is normal. His hemoglobin is 13.2 g/dL, leukocyte count is 9,900/mm, and platelet count is 199,000/mm. Urinalysis shows a proteinuria of 2+, 69 RBC/hbf, and 1-2 WBC/hbf. Chest x-ray shows pulmonary infiltrates. Further testing is most likely to show which of the following?
- Increased anti-PLA2R antibodies
- Increased serum IgA antibodies
- Increased c-ANCA antibodies
- Increased p-ANCA antibodies
- Increased anti-GBM antibodies
- Increased anti-dsDNA antibodies