Yes, a “+” grade and a “-“ grade are weighed differently by medical schools even if your particular undergraduate institution may not. In most cases, the GPA that is reported on your college transcript is going to be slightly different than the GPA that is reported to the medical schools you apply to. Note that an A+ is given a value of 4.0, which is equivalent to an A.

A 4
A- 3.7
B+ 3.3
B 3
B- 2.7
C+ 2.3
C 2
C- 1.7
D+ 1.3
D 1
D- 0.7
F 0.0